ABSTRACT
Background: Insulin resistance has an important role in pathophysiology of polycystic ovarian syndrome [PCOS]. Yet there are certain controversies regarding the presence of insulin resistance in non-obese patients
Objective: The aim was to compare the insulin resistance and various endocrine and metabolic abnormalities in obese and non-obese PCOS women
Materials and Methods: In this cross-sectional study which was performed from 2007-2010, 115 PCOS patients, aged 16-45 years were enrolled. Seventy patients were obese [BMI >/=25] and 45 patients were non-obese [BMI <25]. Presence of insulin resistance and endocrine-metabolic abnormalities were compared between two groups. Collected data were analyzed with SPSS version 16.0 and p<0.05 was considered as statistically significant
Results: There was no significant difference in presence of insulin resistance [HOMA-IR >2.3] between two groups [p=0.357]. Waist circumference [p<0.001], waist/hip ratio [p<0.001], systolic [p<0.001] and diastolic [p<0.001] blood pressures, fasting blood sugar [p=0.003] and insulin [p=0.011], HOMA-IR [p=0.004], total cholesterol [p=0.001] and triglyceride [p<0.001] were all significantly higher in obese PCOS patients. There was no significant difference in total testosterone [p=0.634] and androstenedione [p=0.736] between groups whereas Dehydroepiandrotendione sulfate [DHEAS] was significantly higher in non-obese PCOS women [p=0.018]. There was no case of fatty liver and metabolic syndrome in non-obese patients, whereas they were seen in 31.3% and 39.4% of obese PCOS women, respectively
Conclusion: Our study showed that metabolic abnormalities are more prevalent in obese PCOS women, but adrenal axis activity that is reflected in higher levels of DHEAS was more commonly pronounced in our non-obese PCOS patients
ABSTRACT
Bipolar 1 disorder [BID] and its treatments have shown to be associated with deep impacts on patients' subjective feelings and quality of life [QOL]. There are also some comments about impact of these feelings on course and outcome of patients with BID. This study was aimed to evaluate quality of life in patients with BID and to assess its relationship with course of disorder. Fifty patients with BID were recruited based on the Structured Clinical Interview for DSM-IV Axis I Disorders [SCID-I] from May 2008 and followed for 12 months. Quality of life and mood disorder recurrence were assessed through World Health Organization Quality of Life and SCID-I tools respectively at baseline and after 6 and 12 months. Repeated j measures analysis and logistic regression were used to analyze the independent effect of QOL and demographic factors on BID recurrence. Fifty patients [66% male; 48% never married; 48% in primary school level] with mean +/- SE age and age of BID onset 33.8 +/- 1.5 and 26.6 +/- 1.1 years were studied. They had 3.4 +/- 0.6 episodes already. Twenty eight percent suffered from recurrences during the follow-up. The QOL scores at baseline, after 6 and 12 months were 70 +/- 1.8, 69.6 +/- 1.1 and 73 +/- 1.3 respectively. There were no significant change in QOL and its sub-domains during the follow-up [P=0.37]. QOL showed no independent relationship with BID recurrences [P>0.1]. No change in the QOL during the follow-up could denote lack of effectiveness of routine interventions on this factor. Also, short-term follow-up might be concerned as the f possible reason. Of prime importance is to consider quality of life independently in treating patients with bipolar disorder